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hy p1083  (MedChemExpress)


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    MedChemExpress hy p1083
    Hy P1083, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dynamin+inhibitory+peptide/Dynamin+inhibitory+peptide/pm39264811-827-205-203
    Average 92 stars, based on 1 article reviews
    hy p1083 - by Bioz Stars, 2026-10
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    Article Title: Sevoflurane alters α5β3GABA A receptor trafficking via calcium/calmodulin-dependent protein kinase II-dependent β3 subunit phosphorylation to produce cognitive impairment in aged mice.
    Article Snippet: Background: Sevoflurane increases surface expression of α5 subunit-containing γ-aminobutyric acid type A receptors (GABA A R-α5) and tonic currents in the hippocampus, contributing to postoperative memory decline.. We investigated sevoflurane modulation of the phosphorylation of the β3 subunit which co-assembles with α5 subunits following Ca 2+ / calmodulin-dependent protein kinase II (CaMKII) activation to alter receptor trafficking and exacerbate cognitive dysfunction.. Methods: Aged C57BL/6J mice and primary hippocampal neurones were exposed to 4 vol% sevoflurane for 2 h (Sev group).



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    A , Timeline of the experiments. B , Representative confocal maximum projection images of dendritic sections of mature hippocampal neurons expressing scrambled (shNT) or KCC2a-specific (shKCC2a) shRNA, treated with a <t>dynamin</t> <t>inhibitory</t> peptide (DiP, 50 µM) 40 minutes before and during live Flag immunostaining. Scale: 5 µm. C , Summary boxplot showing the ratio of plasmalemmal (surf.) to the overall (total) KCC2b-Flag immunofluorescence intensity, normalized to control shNT condition. shNT control, n = 37; shNT +DiP, n = 39; shKCC2a control, n = 42; shKCC2a +DiP, n = 41 cells, from 4 independent cultures. Mann-Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. *p < 0.05. D , Representative confocal maximum projection images of dendritic sections of hippocampal neurons expressing scrambled (shNT) or KCC2a-specific shRNA. Two hours before immunostaining with a panKCC2 antibody, neurons were treated with either a proteasome blocker (MG132, 2.5 µM), an inhibitor of the ubiquitin-activating enzyme (PYR-41, 50 µM), or untreated (control). Scale: 5 µm. E , Summary boxplot showing the intensity of endogenous KCC2 immunofluorescence in the different conditions, normalized to shNT control. shNT control, n = 44; shNT +MG132, n = 38; shNT +PYR41, n = 43; shKCC2a control, n = 43; shKCC2a +MG132, n = 40; shKCC2a +PYR41, n = 44 cells, from 4 independent cultures. Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. **p < 0.01.
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    A , Timeline of the experiments. B , Representative confocal maximum projection images of dendritic sections of mature hippocampal neurons expressing scrambled (shNT) or KCC2a-specific (shKCC2a) shRNA, treated with a <t>dynamin</t> <t>inhibitory</t> peptide (DiP, 50 µM) 40 minutes before and during live Flag immunostaining. Scale: 5 µm. C , Summary boxplot showing the ratio of plasmalemmal (surf.) to the overall (total) KCC2b-Flag immunofluorescence intensity, normalized to control shNT condition. shNT control, n = 37; shNT +DiP, n = 39; shKCC2a control, n = 42; shKCC2a +DiP, n = 41 cells, from 4 independent cultures. Mann-Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. *p < 0.05. D , Representative confocal maximum projection images of dendritic sections of hippocampal neurons expressing scrambled (shNT) or KCC2a-specific shRNA. Two hours before immunostaining with a panKCC2 antibody, neurons were treated with either a proteasome blocker (MG132, 2.5 µM), an inhibitor of the ubiquitin-activating enzyme (PYR-41, 50 µM), or untreated (control). Scale: 5 µm. E , Summary boxplot showing the intensity of endogenous KCC2 immunofluorescence in the different conditions, normalized to shNT control. shNT control, n = 44; shNT +MG132, n = 38; shNT +PYR41, n = 43; shKCC2a control, n = 43; shKCC2a +MG132, n = 40; shKCC2a +PYR41, n = 44 cells, from 4 independent cultures. Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. **p < 0.01.
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    A , Timeline of the experiments. B , Representative confocal maximum projection images of dendritic sections of mature hippocampal neurons expressing scrambled (shNT) or KCC2a-specific (shKCC2a) shRNA, treated with a <t>dynamin</t> <t>inhibitory</t> peptide (DiP, 50 µM) 40 minutes before and during live Flag immunostaining. Scale: 5 µm. C , Summary boxplot showing the ratio of plasmalemmal (surf.) to the overall (total) KCC2b-Flag immunofluorescence intensity, normalized to control shNT condition. shNT control, n = 37; shNT +DiP, n = 39; shKCC2a control, n = 42; shKCC2a +DiP, n = 41 cells, from 4 independent cultures. Mann-Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. *p < 0.05. D , Representative confocal maximum projection images of dendritic sections of hippocampal neurons expressing scrambled (shNT) or KCC2a-specific shRNA. Two hours before immunostaining with a panKCC2 antibody, neurons were treated with either a proteasome blocker (MG132, 2.5 µM), an inhibitor of the ubiquitin-activating enzyme (PYR-41, 50 µM), or untreated (control). Scale: 5 µm. E , Summary boxplot showing the intensity of endogenous KCC2 immunofluorescence in the different conditions, normalized to shNT control. shNT control, n = 44; shNT +MG132, n = 38; shNT +PYR41, n = 43; shKCC2a control, n = 43; shKCC2a +MG132, n = 40; shKCC2a +PYR41, n = 44 cells, from 4 independent cultures. Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. **p < 0.01.
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    A , Timeline of the experiments. B , Representative confocal maximum projection images of dendritic sections of mature hippocampal neurons expressing scrambled (shNT) or KCC2a-specific (shKCC2a) shRNA, treated with a <t>dynamin</t> <t>inhibitory</t> peptide (DiP, 50 µM) 40 minutes before and during live Flag immunostaining. Scale: 5 µm. C , Summary boxplot showing the ratio of plasmalemmal (surf.) to the overall (total) KCC2b-Flag immunofluorescence intensity, normalized to control shNT condition. shNT control, n = 37; shNT +DiP, n = 39; shKCC2a control, n = 42; shKCC2a +DiP, n = 41 cells, from 4 independent cultures. Mann-Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. *p < 0.05. D , Representative confocal maximum projection images of dendritic sections of hippocampal neurons expressing scrambled (shNT) or KCC2a-specific shRNA. Two hours before immunostaining with a panKCC2 antibody, neurons were treated with either a proteasome blocker (MG132, 2.5 µM), an inhibitor of the ubiquitin-activating enzyme (PYR-41, 50 µM), or untreated (control). Scale: 5 µm. E , Summary boxplot showing the intensity of endogenous KCC2 immunofluorescence in the different conditions, normalized to shNT control. shNT control, n = 44; shNT +MG132, n = 38; shNT +PYR41, n = 43; shKCC2a control, n = 43; shKCC2a +MG132, n = 40; shKCC2a +PYR41, n = 44 cells, from 4 independent cultures. Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. **p < 0.01.
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    A , Timeline of the experiments. B , Representative confocal maximum projection images of dendritic sections of mature hippocampal neurons expressing scrambled (shNT) or KCC2a-specific (shKCC2a) shRNA, treated with a dynamin inhibitory peptide (DiP, 50 µM) 40 minutes before and during live Flag immunostaining. Scale: 5 µm. C , Summary boxplot showing the ratio of plasmalemmal (surf.) to the overall (total) KCC2b-Flag immunofluorescence intensity, normalized to control shNT condition. shNT control, n = 37; shNT +DiP, n = 39; shKCC2a control, n = 42; shKCC2a +DiP, n = 41 cells, from 4 independent cultures. Mann-Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. *p < 0.05. D , Representative confocal maximum projection images of dendritic sections of hippocampal neurons expressing scrambled (shNT) or KCC2a-specific shRNA. Two hours before immunostaining with a panKCC2 antibody, neurons were treated with either a proteasome blocker (MG132, 2.5 µM), an inhibitor of the ubiquitin-activating enzyme (PYR-41, 50 µM), or untreated (control). Scale: 5 µm. E , Summary boxplot showing the intensity of endogenous KCC2 immunofluorescence in the different conditions, normalized to shNT control. shNT control, n = 44; shNT +MG132, n = 38; shNT +PYR41, n = 43; shKCC2a control, n = 43; shKCC2a +MG132, n = 40; shKCC2a +PYR41, n = 44 cells, from 4 independent cultures. Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. **p < 0.01.

    Journal: bioRxiv

    Article Title: Differential isoform-specific control of KCC2 function in developing cortical neurons

    doi: 10.64898/2026.01.25.701648

    Figure Lengend Snippet: A , Timeline of the experiments. B , Representative confocal maximum projection images of dendritic sections of mature hippocampal neurons expressing scrambled (shNT) or KCC2a-specific (shKCC2a) shRNA, treated with a dynamin inhibitory peptide (DiP, 50 µM) 40 minutes before and during live Flag immunostaining. Scale: 5 µm. C , Summary boxplot showing the ratio of plasmalemmal (surf.) to the overall (total) KCC2b-Flag immunofluorescence intensity, normalized to control shNT condition. shNT control, n = 37; shNT +DiP, n = 39; shKCC2a control, n = 42; shKCC2a +DiP, n = 41 cells, from 4 independent cultures. Mann-Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. *p < 0.05. D , Representative confocal maximum projection images of dendritic sections of hippocampal neurons expressing scrambled (shNT) or KCC2a-specific shRNA. Two hours before immunostaining with a panKCC2 antibody, neurons were treated with either a proteasome blocker (MG132, 2.5 µM), an inhibitor of the ubiquitin-activating enzyme (PYR-41, 50 µM), or untreated (control). Scale: 5 µm. E , Summary boxplot showing the intensity of endogenous KCC2 immunofluorescence in the different conditions, normalized to shNT control. shNT control, n = 44; shNT +MG132, n = 38; shNT +PYR41, n = 43; shKCC2a control, n = 43; shKCC2a +MG132, n = 40; shKCC2a +PYR41, n = 44 cells, from 4 independent cultures. Whitney rank-sum tests, p-value corrected for multiple comparisons using the Holm-Šídák method. **p < 0.01.

    Article Snippet: Clathrin-mediated endocytosis was inhibited by incubating neurons for 40 min with the Dynamin Inhibitory Peptide, myristoylated (DiP) (50 μM, MedChemExpress) in complete culture medium at 37°C.

    Techniques: Expressing, shRNA, Immunostaining, Immunofluorescence, Control, MANN-WHITNEY, Ubiquitin Proteomics